| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
International Journal of Systematic and Evolutionary Microbiology, Vol 50, 1673-1681, Copyright © 2000 by Society for General Microbiology
G Zhu, JS Keithly and H Philippe
Wadsworth Center, New York State Department of Health, David Axelrod Institute for Public Health, 120 New Scotland Avenue, Albany, NY 12201-2002, USA
The phylogenetic position of Cryptosporidium is elusive. Although previous studies based solely upon small-subunit (SSU) rRNA sequences suggested that the genus was an early emerging lineage among the Apicomplexa, bootstrap support for this placement was low. Here, the phylogenetic position of Cryptosporidium has been re-evaluated for SSU rRNA, fused SSU/large-subunit (LSU) rRNA and six protein sequences using traditional distance-based neighbour-joining, maximum-parsimony and maximum-likelihood methods of phylogenetic reconstruction as well as the new Slow--Fast analysis, which focuses upon the slowly evolving positions within sequences and is especially useful if a long-branch attraction (LBA) artefact is suspected. All the methods of reconstruction indicated a trend for the early emergence of Cryptosporidium at the base of the Apicomplexa and showed that an LBA artefact plays no role in this placement. Although the inclusion of additional numbers of neither species nor genes has significantly enhanced the bootstrap support for this phylogenetic position, recent biochemical, molecular and ultrastructural data are congruent with it. Therefore, we favour a working hypothesis that this genus constitutes an early emerging branch of the Apicomplexa.
This article has been cited by other articles:
|
|
 |
|
  C.-H. Kuo, J. P. Wares, and J. C. Kissinger The Apicomplexan Whole-Genome Phylogeny: An Analysis of Incongruence among Gene Trees Mol. Biol. Evol., December 1, 2008; 25(12): 2689 - 2698. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Zeng, X. Cai, and G. Zhu Functional characterization of a fatty acyl-CoA-binding protein (ACBP) from the apicomplexan Cryptosporidium parvum. Microbiology, August 1, 2006; 152(Pt 8): 2355 - 2363. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Loriol, F. Dupuy, R. Rampal, M.A. Dlugosz, R.S. Haltiwanger, A. Maftah, and A. Germot Molecular evolution of protein O-fucosyltransferase genes and splice variants Glycobiology, August 1, 2006; 16(8): 736 - 747. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Cai, K. M. Woods, S. J. Upton, and G. Zhu Application of Quantitative Real-Time Reverse Transcription-PCR in Assessing Drug Efficacy against the Intracellular Pathogen Cryptosporidium parvum In Vitro Antimicrob. Agents Chemother., November 1, 2005; 49(11): 4437 - 4442. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Naude, J. A. Brzostowski, A. R. Kimmel, and T. E. Wellems Dictyostelium discoideum Expresses a Malaria Chloroquine Resistance Mechanism upon Transfection with Mutant, but Not Wild-type, Plasmodium falciparum Transporter PfCRT J. Biol. Chem., July 8, 2005; 280(27): 25596 - 25603. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X.-M. Chen, S. P. O'Hara, B. Q. Huang, J. B. Nelson, J. J.-C. Lin, G. Zhu, H. D. Ward, and N. F. LaRusso Apical Organelle Discharge by Cryptosporidium parvum Is Temperature, Cytoskeleton, and Intracellular Calcium Dependent and Required for Host Cell Invasion Infect. Immun., December 1, 2004; 72(12): 6806 - 6816. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. J. Templeton, L. M. Iyer, V. Anantharaman, S. Enomoto, J. E. Abrahante, G.M. Subramanian, S. L. Hoffman, M. S. Abrahamsen, and L. Aravind Comparative Analysis of Apicomplexa and Genomic Diversity in Eukaryotes Genome Res., September 1, 2004; 14(9): 1686 - 1695. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Templeton, C. A. Lancto, V. Vigdorovich, C. Liu, N. R. London, K. Z. Hadsall, and M. S. Abrahamsen The Cryptosporidium Oocyst Wall Protein Is a Member of a Multigene Family and Has a Homolog in Toxoplasma Infect. Immun., February 1, 2004; 72(2): 980 - 987. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. S. Leander, R. E. Clopton, and P. J. Keeling Phylogeny of gregarines (Apicomplexa) as inferred from small-subunit rDNA and {beta}-tubulin Int J Syst Evol Microbiol, January 1, 2003; 53(1): 345 - 354. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. S. Yoon, J. D. Hackett, G. Pinto, and D. Bhattacharya From the Cover: The single, ancient origin of chromist plastids PNAS, November 26, 2002; 99(24): 15507 - 15512. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X.-M. Chen, J. S. Keithly, C. V. Paya, and N. F. LaRusso Cryptosporidiosis N. Engl. J. Med., May 30, 2002; 346(22): 1723 - 1731. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| INT J SYST EVOL MICROBIOL | MICROBIOLOGY | J GEN VIROL |
| J MED MICROBIOL | ALL SGM JOURNALS | |
