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International Journal of Systematic and Evolutionary Microbiology, Vol 50, 1007-1011, Copyright © 2000 by Society for General Microbiology
HP Hinrikson, F Dutly and M Altwegg
Department of Medical Microbiology, University of Zurich, Gloriastrasse 30, 8028 Zurich, Switzerland
Heterogeneity in the 16S--23S rDNA spacer of uncultured 'Tropheryma whippelii' has previously been reported. In this study, the hypervariable insertion in the 23S rDNA domain III characteristic for actinobacteria was analysed. The finding of a unique sequence virtually identical among the subtypes supports the classification of 'T. whippelii' among the actinobacteria and the concept of three subtypes rather than three subspecies, and provides an alternative target for diagnostic assays.
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